Wood dust exposure and small cell lung cancer: a systematic review and meta-analysis
- Curiel-García, Teresa
- Candal-Pedreira, Cristina
- Varela-Lema, Leonor
- Rey-Brandariz, Julia
- Casal-Acción, Beatriz
- Moure-Rodríguez, Lucía
- Figueiras, Adolfo
- Ruano-Ravina, Alberto
- Pérez-Ríos, Mónica
ISSN: 1559-0631, 1559-064X
Ano de publicación: 2023
Tipo: Artigo
Outras publicacións en: Journal of Exposure Science & Environmental Epidemiology
Obxectivos de Desenvolvemento Sustentable
Resumo
Introduction: Occupational exposure role on small cell lung cancer (SCLC) onset has been little studied. Wood dust has been recognized as a human carcinogen, and many occupations have high wood-dust exposure. The aim of this study was therefore to perform a systematic review and meta-analysis of the scientific literature to summarize and analyse the risks of wood dust-related occupations on development of SCLC, taking tobacco use into account. Methods: We conducted a literature search of PubMed, EMBASE, Web of Science and Cochrane using a predefined strategy and including case-control and cohort studies assessing occupational exposure to wood dust or wood dust-related occupations. To perform the meta-analysis, the odds ratio (OR) and 95% confidence interval (CI) of each of the studies were extracted. A random-effects model was fitted using the DerSimonian Laird method. Sensitivity and subgroup analyses were performed. Quality was assessed using the Office and Health Assessment and Translation (OHAT) for human and animal studies instrument. Results: Eleven studies with a total of 2,368 SCLC cases and 357,179 controls were included. Overall, exposure to wood dust significantly increases risk of SCLC (RR = 1.41, 95% CI 1.11–1.80), with low heterogeneity between studies (I2 = 40%). The association was maintained in studies conducted on males (RR = 1.41, 95% CI 1.12–1.78) but not in those conducted on females/both sexes (RR = 1.37, 95% CI 0.35–3.44). Sensitivity analysis showed that none of the studies significantly modified the results. Conclusions: Our results support that exposure to wood-dust can increase the risk of SCLC. Although the level of evidence is low, there are strong arguments to recommend the implementation of effective control measures to reduce exposure in occupational settings, as a means of preventing SCLC. Impact statement: The results of this study support that exposure to wood-dust can increase the risk of developing small cell lung cancer. Determining the impact of occupational exposure on workers is essential to improve their individual protection and prevention. There is a strong case for recommending the implementation of control measures to reduce occupational exposure to wood dust, specifically for highly exposed occupations such as carpenters and sawmills, in order to prevent small cell lung cancer.
Información de financiamento
This research has been funded by a research project (1215/2022) awarded by the Spanish Society of Respiratory Pathology (SEPAR), entitled “Occupation and lung cancer. A pooling study in Northwestern Spain”.Financiadores
- Spanish Society of Respiratory Pathology
- Sociedad Española de Neumología y Cirugía Torácica Spain
Referencias bibliográficas
- National Cancer Institute. Surveillance, Epidemiology, and End Results Program. [cited 2023 Jan 4]. Available from: https://seer.cancer.gov/.
- Tseng J-S, Chiang C-J, Chen K-C, Zheng Z-R, Yang T-Y, Lee W-C, et al. Association of smoking with patient characteristics and outcomes in small cell lung carcinoma, 2011–2018. JAMA Netw Open. 2022;5:e224830–e224830.
- Lubin JH, Blot WJ. Assessment of lung cancer risk factors by histologic category. J Natl Cancer Inst. 1984;73:383–9.
- Boulanger M, Tual S, Lemarchand C, Guizard AV, Delafosse P, Marcotullio E, et al. Lung cancer risk and occupational exposures in crop farming: results from the AGRIculture and CANcer (AGRICAN) cohort. Occup Environ Med. 2018;75:776–85.
- Osann KE, Lowery JT, Schell MJ. Small cell lung cancer in women: Risk associated with smoking, prior respiratory disease, and occupation. Lung Cancer. 2000;28:1–10. http://www.lungcancerjournal.info/article/S0169500299001063/fulltext.
- Olsson AC, Vermeulen R, Schüz J, Kromhout H, Pesch B, Peters S, et al. Exposure-response analyses of asbestos and lung cancer subtypes in a pooled analysis of case-control studies. Epidemiology 2017;28:288–99.
- IARC. Arsenic, metals, fibres, and Dusts. Iarc Monogr. 2012;100c(Arsenic, metals, fibres, and dusts).
- IARC. Evaluation of carcinogenic risks to humans: wood dust and formaldehyde. IARC Monogr Eval Carcinog Risks Hum. 1995;62:217–362.
- Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://www.bmj.com/content/372/bmj.n71.
- STROBE. Strengthening the reporting of observational studies in epidemiology [Internet]. [cited 2022 Oct 15]. Available from: https://www.strobe-statement.org/
- EPIDAT 3.1 - Consellería de Sanidade - Servizo Galego de Saúde. Available from: https://www.sergas.es/Saude-publica/Epidat-3-1-descargar-Epidat-3-1-(espanol).
- Office of Health Assessment and Translation. OHAT Risk of Bias Rating Tool for Human and Animal Studies. Natl Toxicol Progr. 2019;(January):1–37. Available from: https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/riskbias/index.html.
- Cochrane. 9.5.2 Identifying and measuring heterogeneity. [cited 2023 Jan 4]. Available from: https://handbook-5-1.cochrane.org/chapter_9/9_5_2_identifying_and_measuring_heterogeneity.htm.
- Wu X, Delclos GL, Annegers JF, Bondy ML, Honn SE, Henry B, et al. A Case-Control Study of Wood Dust Exposure, Mutagen Sensitivity, and Lung Cancer Risk’
- Barcenas CH, Delclos GL, El-Zein R, Tortolero-Luna G, Whitehead LW, Spitz MR. Wood dust exposure and the association with lung cancer risk. Am J Ind Med. 2005;47:349–57.
- Jayaprakash V, Natarajan KK, Moysich KB, Rigual NR, Ramnath N, Natarajan N, et al. Wood dust exposure and the risk of upper aero-digestive and respiratory cancers in males. Occup Environ Med. 2008;65:647–54.
- Blot WJ, Davies JE, Brown LM, Nordwall CW, Buiatti E, Ng A, et al. Occupation and the high risk of lung cancer in Northeast Florida. Cancer 1982;50:364–71.
- De Stefani E, Kogevinas M, Boffetta P, Ronco A, Mendilaharsu M. Occupation and the risk of lung cancer in Uruguay. Scand J Work Environ Health. 1996;22:346–52. https://pubmed.ncbi.nlm.nih.gov/8923607/.
- Vallières E, Pintos J, Parent ME, Siemiatycki J. Occupational exposure to wood dust and risk of lung cancer in two population-based case-control studies in Montreal, Canada. Environ Health. 2015;14:1. https://pubmed.ncbi.nlm.nih.gov/25564290/.
- MacArthur AC, Le ND, Fang R, Band PR. Identification of occupational cancer risk in British Columbia: a population-based case-control study of 2,998 lung cancers by histopathological subtype. Am J Ind Med. 2009;52:221–32.
- Yenugadhati N, Birkett NJ, Momoli F, Krewski D. Occupations and lung cancer: a population-based case-control study in British Columbia. J Toxicol Environ Health A 2009;72:658–75.
- Zahm SH, Brownson RC, Chang JC, Davis JR. Study of lung cancer histologic types, occupation, and smoking in Missouri. Am J Ind Med. 1989;15:565–78.
- Calvert N, Hind D, McWilliams RG, Thomas SM, Beverley C, Davidson A. The effectiveness and cost-effectiveness of ultrasound locating devices for central venous access: a systematic review and economic evaluation. NIHR Health Technology Assessment programme NIHR Journals Library, National Institute for Health and Care Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK journals.: NIHR Health Technology Assessment programme; 2003.
- Calvert GM, Luckhaupt S, Lee SJ, Cress R, Schumacher P, Shen R, et al. Lung cancer risk among construction workers in California, 1988–2007. Am J Ind Med. 2012;55:412–22.
- Ruano-Ravina A, Figueiras A, Barreiro-Carracedo MA, Barros-Dios J. Occupation and smoking as risk factors for lung cancer: a population-based case-control study. Am J Ind Med. 2003;43:149–55. https://onlinelibrary.wiley.com/doi/full/10.1002/ajim.10171.
- Steenland K, Thun M. Interaction between tobacco smoking and occupational exposures in the causation of lung cancer. J Occup Med. 1986;28:110–8.
- Williams MD, Sandler AB. The epidemiology of lung cancer. Cancer Treat Res. 2001;105:31–52.