The sea lamprey GABAB receptorChanges after spinal cord injury and its role in axonal regeneration

  1. Romaus Sanjurjo, Daniel
Supervised by:
  1. María Celina Rodicio Director
  2. Antón Barreiro Iglesias Co-director

Defence university: Universidade de Santiago de Compostela

Fecha de defensa: 20 April 2018

Committee:
  1. Ramon Anadon Vazquez Chair
  2. Idoia Quintana Urzainqui Secretary
  3. Arsenio Fernández López Committee member

Type: Thesis

Teseo: 549817 DIALNET

Abstract

Spinal cord injury (SCI) causes irreversible loss of function. In contrast to mammals, lampreys show an amazing capacity for spontaneous recovery after a complete SCI. In this study, we analysed the changes in the expression of both gabab subunits after a complete SCI. Our results showed that plastic changes in this system probably contribute to the recovery of function after SCI in lampreys. Pharmacological and genetic manipulations revealed that GABA acting through GABAB receptors promotes axonal regeneration of descending neurons after a complete SCI in lampreys.