Hipercortisolismo de origen adrenal
- C. Guillín 1
- I. Bernabeu 1
- I.A. Rodríguez-Gómez 2
- F.F. Casanueva 1
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1
Complexo Hospitalario Universitario de Santiago
info
Complexo Hospitalario Universitario de Santiago
Santiago de Compostela, España
- 2 Unidad de Endocrinología y Nutrición. Hospital HM Modelo. La Coruña. España
ISSN: 0304-5412
Year of publication: 2016
Issue Title: Enfermedades endocrinológicas y metabólicas (II) Patología suprarrenal
Series: 12
Issue: 14
Pages: 781-786
Type: Article
More publications in: Medicine: Programa de Formación Médica Continuada Acreditado
Abstract
Introduction The Cushing's syndrome results from a chronic exposure to high levels of glucocorticoids. The most common cause of hypercortisolism is the exogenous or pharmacological one. Within the endogenous causes, they can be corticotropin-dependent (ie. pituitary origin) or independent (ie. adrenal origin). History and clinical examination Cushing's syndrome is characterized by a variable combination of symptoms affecting several organs and systems: centripetal obesity, insulin resistance, dyslipidaemia, reproductive dysfunction, skin weakness, osteoporosis and even psychiatric disorders, among others. Evaluation In patients with clinical suspicion of Cushing's syndrome, and once discarded the exogenous causes, we have to biochemically confirm the hypercortisolism, identify whether it is corticotropin dependent or independent and, finally, try locate the source of hormonal excess. Treatment The treatment of choice is surgery. Medical treatment is indicated when surgery is postponed, contraindicated or unsuccessful.
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