Linfomas orbitariosPresentación de nueve casos

  1. C. Rey-Porca
  2. M. Pérez-Encinas
  3. F. González
Revista:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Ano de publicación: 2008

Volume: 83

Número: 2

Páxinas: 95-104

Tipo: Artigo

DOI: 10.4321/S0365-66912008000200007 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Archivos de la Sociedad Española de Oftalmologia

Obxectivos de Desenvolvemento Sustentable

Resumo

Purpose: To report nine cases of orbital lymphomas. Methods: We reviewed the clinical records of nine patients diagnosed with orbital lymphoma and performed a literature search related to this condition. Results: We present a series of five women and four males with orbital lymphoma involving the orbital region. In our cases, most patients presented concurrent extraorbital lymphoma when the orbital disease was first noticed (seven out of nine patients). We found three MALT lymphomas, two follicular lymphomas, two non-Hodgkin large B cell lymphomas, one low grade B cell lymphoma, and one mantle cell lymphoma. Eight patients were alive and one had died as a consequence of his lymphoma at the time this report was written. Conclusions: An increase in the incidence of non-Hodgkin orbital lymphomas has been observed over the last three decades. The most common type in the orbital region is the MALT lymphoma. The clinical features observed in our series are similar to those reported in the literature. Since lymphomas are the most frequent malignant tumours in the orbit, usually with extraorbital involvement, and can be successfully treated in many cases, it is important for the ophthalmologist to be aware of this condition.

Referencias bibliográficas

  • Shields, JA, Shields, CL, Scartozzi, R. (2004). Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 111. 997-1008
  • Decaudin, D, de Cremoux, P, Vicent-Salomon, A, Dendale, R, Rouic, LL. (2006). Ocular adnexal lymphoma: a review of clinicopathologic features and treatment options. Blood. 108. 1451-1460
  • Coupland, SE, Hummel, M, Stein, H. (2002). Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol. 47. 470-490
  • Coupland, SE, Krause, L, Delecluse, HJ, Anagnostopoulos, I, Foss, HD, Hummel, M. (1998). Lymphoproliferative lesions of the ocular adnexa: Analysis of 112 cases. Ophthalmology. 105. 1430-1441
  • Knowles, DM, Jacobiec, FA, McNally, L, Burke, JS. (1990). Lymphoid hyperplasia and malignant lymphoma ocurring in the ocular adnexa (orbit, conjunctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. Hum Pathol. 21. 959-973
  • Auw-Haedrich, C, Coupland, SE, Kapp, A, Schmitt-Gräff, A, Buchen, R, Witschel, H. (2001). Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification: Revised European and American lymphoma. Br J Ophthalmol. 85. 63-69
  • Jenkins, C, Rose, GE, Bunce, C, Wright, JE, Cree, IA, Plowman, N. (2000). Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbility and survival. Br J Ophthalmol. 84. 907-913
  • Shields, CL, Shields, JA, Carvalho, C, Rundle, P, Smith, AF. (2001). Conjuntival lymphoid tumors: clinical analysis of 117 cases and relationship to systemic lymphoma. Ophthalmology. 108. 979-984
  • Meunier, J, Lumbroso-Le Rouic, L, Vicent-Salomon, A, Dendale, R, Asselain, B, Arnaud, P. (2004). Ophthalmologic and intraocular non-Hodgkin´s lymphoma: a large single center study of inicial characteristics, natural history, and pronostic factors. Hematol Oncol. 22. 143-158
  • White, WL, Ferry, JA, Harris, NL, Grove, AS Jr. (1995). Ocular adnexal lymphoma: A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology. 102. 1994-2006
  • Martinet, S, Ozsahin, M, Belkacémi, Y, Landmann, C, Poormans, P, Oehlere, C. (2003). Outcome and prognostic factors in orbital lymphoma: a Rare Cancer Network study on 90 consecutive patients treated with radiotherapy. Int J Radiat Oncol Biol Phys. 55. 892-898
  • Uno, T, Isobe, K, Shikama, N, Nishikawa, A, Oguchi, M, Ueno, N. (2003). Radiotherapy for extranodal, marginal-zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa: a multiinstitutional, retrospective review of 50 patients. Cancer. 98. 865-871
  • McNally, L, Jakobiec, FA, Knowles, DM. (1987). Clinical, morphologic, immunophenotypic, and molecular genetic analysis of bilateral ocular adnexal lymphoid neoplasms in 17 patients. Am J Ophthalmol. 103. 555-568
  • Johnson, TE, Tse, DT, Byrne, GE Jr, Restrepo, A, Whitcomb, CC, Voigt, W. (1999). Ocular-adnexal lymphoid tumors: a clinicopathologic and molecular genetic study of 77 patients. Ophthal Plast Reconstr Surg. 15. 171-179
  • McKelvie, PA, McNab, A, Francis, IC, Fox, R, O´Day, J. (2001). Ocular adnexal lymphoproliferative disease: a series of 73 cases. Clin Experiment Ophthalmol. 29. 387-393
  • Ferreri, AJ, Ponzoni, M, Guidoboni, M, Resti, AG, Politi, LS, Cortelazzo, S. (2006). Bacteria-eradicating therapy with doxycycline in ocular adnexal MALT lymphoma: a multicenter prospective trial. J Natl Cancer Inst. 98. 1375-1382
  • Shen, D, Yuen, HK, Galita, DA, Chan, NR, Chan, CC. (2006). Detection of Chlamydia pneumoniae in a bilateral orbital mucosa-associated lymphoid tissue lymphoma. Am J Ophthalmol. 141. 1162-1163
  • Moslehi, R, Devesa, SS, Schairer, C, Fraumeni, JF Jr. (2006). Rapidly increasing incidence of ocular non-hodgkin lymphoma. J Natl Cancer Inst. 98. 936-939
Fonte de datos: Dialnet