Triple terapia en diabetes tipo 2: revisión sistemática de la evidencia disponible

  1. Carlos Ortega Millán
  2. José Antonio Fornos Pérez
  3. Ricardo Víctor García Mayor
  4. Edelmiro Menéndez Torre
Revista:
Avances en diabetología

ISSN: 1134-3230

Ano de publicación: 2010

Volume: 26

Número: 4

Páxinas: 276-280

Tipo: Artigo

DOI: 10.1016/S1134-3230(10)64016-1 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Avances en diabetología

Obxectivos de Desenvolvemento Sustentable

Resumo

Current guidelines differ in their recommendations for triple therapy when targets are not achieved with a combined treatment of two oral agents. In addition, they diverge also in the type of association and the name given for the triple therapy. In the present manuscript we review the available scientific evidence to determine whether triple therapy is effective and safe, as well as the more favorable association in patients with type 2 diabetes. Reviewing available literature, we have noticed that triple therapy improves glycemic control. However, available randomized control trials do not extend more than one year of follow-up and they don't have data over endpoint variables as morbidity and mortality. Therefore, the long-term safety of triple therapy has not been demonstrated until now. In conclusion, with the currently available data there is no reason to delay introduction of insulin in the treatment of patients with type 2 diabetes after failure of dual combination therapy, except in cases of patients' resistance to initiate insulin therapy.