Estudios controlados en humanos de éxtasis

  1. Segura Agulló, Mireia
  2. Pizarro Lozano, Nieves
  3. Abanades León, Sergio
  4. Peiró Peiró, Ana M.
  5. Roset Arissó, Pere N.
  6. García Álvarez, Yolanda
  7. Farré Albaladejo, Magí
  8. de la Torre Fornell, Rafael
  9. Poudevida Jürschik, Sandra
Journal:
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Year of publication: 2003

Volume: 15

Issue: 2

Pages: 121-134

Type: Article

DOI: 10.20882/ADICCIONES.457 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Adicciones: Revista de socidrogalcohol

Sustainable development goals

Abstract

Objetivo: recopilar y analizar la información sobre los efectos de la MDMA obtenida en estudios controlados en humanos. Método: la mayoría de ensayos analizados han sido de diseño enmascarado a doble ciego, cruzados, con asignación aleatoria a la secuencia de tratamientos, y controlados con placebo y/o fármaco patrón. Resultados: además del incremento de la presión y frecuencia cardíaca, la MDMA incrementa el consumo miocárdico de oxígeno sin efectos inotrópicos y puede incrementar el intervalo QTc en el ECG. El aumento de temperatura no fue significativo frente a placebo. Produce euforia, bienestar y activación. No se han descrito ni alucinaciones ni ilusiones. En el EEG aumenta la actividad beta y disminuye la alfa. Aumenta de forma dosis-dependiente las concentraciones de ACTH, cortisol, prolactina, dihidroepiandrosterona y vasopresina. Inmunológicamente su efecto parece ser inmunosupresor. Su farmacocinética parece ser no-lineal con tendencia a la acumulación a dosis alta. Conclusiones: los estudios controlados han permitido conocer mejor la MDMA, profundizando en sus efectos subjetivos, y aportando datos originales en cuanto a cambios hormonales e inmunológicos. Se necesitan más estudios para determinar científicamente los efectos y toxicidad de la MDMA.

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