Comorbilidad psiquiátrica y valores plasmáticos de 2-acilgliceroles en consumidores de alcohol en tratamiento ambulatorio. Análisis de las diferencias de género

  1. Nuria García Marchena 1
  2. Pedro Araos 1
  3. Francisco Javier Pavón 1
  4. Guillermo Ponce 2
  5. María Pedraz 1
  6. Antonia Serrano 1
  7. Francisco Arias 2
  8. Pablo Romero-Sanchiz 1
  9. Juan Suárez 1
  10. Antoni Pastor 3
  11. Rafael de la Torre 3
  12. Marta Torrens 3
  13. Gabriel Rubio 1
  14. Fernando Rodríguez de Fonseca 1
  1. 1 Instituto de Investigación Biomédica de Málaga
    info

    Instituto de Investigación Biomédica de Málaga

    Málaga, España

    ROR https://ror.org/05n3asa33

  2. 2 Instituto de Investigación I+12, Hospital 12 de Octubre
  3. 3 INAD
Mostrar afiliacións +
Revista:
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Ano de publicación: 2017

Volume: 29

Número: 2

Páxinas: 83-96

Tipo: Artigo

DOI: 10.20882/ADICCIONES.931 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Adicciones: Revista de socidrogalcohol

Obxectivos de Desenvolvemento Sustentable

Resumo

Alcohol addiction is associated with high psychiatric comorbidity. Objective stratification of patients is necessary to optimize care and improve prognosis. The present study is designed to gain insights into this challenge by addressing the following objectives: a) to estimate the prevalence of psychiatric comorbidities in a sample of outpatients seeking treatment for alcohol use disorder, b) to describe the existence of gender differences and c) to validate 2-acyl-glycerols as biomarkers of alcohol use disorder and/or psychiatric comorbidity. One hundred and sixty-two patients were recruited and evaluated with the semistructured interview PRISM. The presence of psychopathology was associated with a greater number of criteria for alcohol abuse and dependence according to DSM-IV-TR. We found gender differences in psychiatric comorbidity, e.g., mood disorder, as well as in comorbid substance use disorders. The prevalence of lifetime psychiatric comorbidity was 68.5%, with mood disorders the most frequent (37%), followed by attention deficit disorder (24.7%) and anxiety disorders (17.9%). Substance-induced disorders were more frequent in mood and psychotic disorders, whereas the primary disorders were more prevalent in patients with comorbid anxiety disorders. We found that 2-acyl-glycerols were significantly decreased in comorbid anxiety disorders in alcohol dependent patients in the last year, which makes them a potential biomarker for this psychopathological condition.

Referencias bibliográficas

  • Alegría, A. A., Blanco, C., Petry, N. M., Skodol, A. E., Liu, S. M., Grant, B. y Hasin, D. (2013). Sex differences in antisocial personality disorder: results from the national epidemiological survey on alcohol and related conditions. Personal Disorders, 4, 214-222.doi: 10.1037/a0031681.
  • Araos, P., Vergara-Moragues, E., Pedraz, M., Pavón, F.J., Campos, R., Calado, M.,… Rodríguez de Fonseca, F. (2014). Comorbilidad psicopatológica en consumidores de cocaína en tratamiento ambulatorio. Adicciones, 26, 15-26.
  • Ávila Escribano, J. J. y González Parra, D. (2007). Gender differences in alcoholism. Adicciones, 19,383-392.
  • Basavarajappa, B. S. y Hungrund, B. L. (2005). Role of the endocannabinoid system in the development of tolerance to alcohol. Alcohol and Alcoholism, 40, 15-24.
  • Blanco, C., Iza, M., Rodríguez-Fernández, J. M., Baca-García, E., Wang, S. y Olfson, M. (2015). Probability and predictors of treatment-seeking for substance use disorders in the U.S. Drug and Alcohol Dependence, 149, 136-144. doi: 10.1016/j.drugalcdep.2015.01.031.
  • Caillé, S., Alvarez-Jaimes, L. Polis, I., Stouffer, D. G. y Parsons, L. H. (2007). Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. The Journal of Neuroscience, 27, 3695-3702.
  • Boschloo, L., Van den Brink, W., Penninx, B. W. J. H., Wall, M. M. y Hasin, D. S. (2012). Alcohol-use disorder severity predicts first-incidence of depressive disorders. Psychological Medicine, 42, 695-703. doi: 10.1017/S0033291711001681.
  • Driessen, M., Veltrup, C., Wetterling, T., John, U. y Dilling, H. (1998). Axis I and Axis II comorbidity in alcohol dependence and the two types or alcoholism). Alcoholism: Clinical and Experimental Research, 22,77-86.
  • Daigre, C., Terán, A., García-Vicent, V. y Roncero, C. (2013). Trastorno por déficit de atención con hiperactividad y dependencia de sustancias depresoras. Adicciones, 25, 171-186.
  • Engelhard, C. P., Touquet, G., Tansens, A. y De Fruyt, J. (2015). [Alcohol-induced psychotic disorder: a systematic literature review]. Tijdschrift voor Psychiatrie, 57, 192-201.
  • Fernández-Montalvo, J., Landa, N., López-Goñi, J. J. y Lorea, I. (2006). Personality disorders in alcoholics: A comparative pilot study between the IPDE and the MCMI-II. Addictive Behaviors, 31, 1442-1448.
  • Fiedler, K. K., Kim, N., Kondo, D. G. y Renshaw, P. F. (2012). Cocaine use in the past year is associated with altitude of residence. Journal of Addiction Medicine, 6,166-171. doi: 10.1097/ADM.0b013e31824b6c62.
  • Flensborg-Madsen, T., Knop, J. Mortensen, E. L., Becker, U., Sher, L. y Gronbaek, M. (2009). Alcohol use disorders increase the risk of completed suicide-irrespective of other psychiatric disorders. A longitudinal cohort study. Psychiatry Research, 167, 123-130. doi: 10.1016/j.psychres.2008.01.008.
  • Gaetani, S., Cuomo, V. y Piomelli, D. (2003). Anandamide hydrolysis: a new target for anti-anxiety drugs?. Trends in Molecular Medicine, 9, 478-478.
  • Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Ruan, W. J. y Pickering, R. P. (2004). Co-occurrence of 12-Month Alcohol and Drug Use Disorders and PersonalityDisorders in the United States: Results From the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 61,361-368.
  • Goldsmith, R. J. (1999). Overview of psychiatric comorbidity: practical and theoretic considerations. Psychiatric Clinics of North America, 22,331-349.
  • Guggenhuber, S., Romo-Parra, H., Bindila, L., Leschik, J., Lomazzo, E., Remmers, F.,… Lutz, B. (2015). Impaired 2-AG signaling in hippocampal glutamatergic neurons: aggravation of anxiety-Like behavior and unaltered seizure susceptibility. International Journal of Neuropsychopharmacology, pyv091. doi: 10.1093/ijnp/pyv091.
  • Hasin, D. S., Trautman, K. D., Miele, G. M., Samet, S., Smith, M. y Endicott, J. (1996). Psychiatric Research Interview for Substance and Mental Disorders (PRISM): Reliability for substance abusers. American Journal of Psychiatry, 153, 1195-1201.
  • Hasin, D. S., Goodwin, R. D., Stinson, F. S. y Grant, B. F. (2005). Epidemiology of Major Depressive Disorder: Results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Archives of General Psychiatry, 62,1097-1106.
  • Hasin, D. S., Stinson, F. S., Ogburn, E. y Grant, B. F. (2007). Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 64,830-842.
  • Jenniches, I., Ternes, S., Albayram, O., Otte, D. M., Bach, K., Bindila, L.,… Zimmer, A. (2015). Anxiety, stress and fear response in mice with reduced endocannabinoid levels. Biological Psychiatry. doi: 10.1016/j.biopsych.2015.03.033.
  • Karila, L., Petit, A., Lowenstein, W. y Reynaud, M. (2012). Diagnosis and consequences of cocaine addiction. Current Medical Chemistry, 19,5612-5618.
  • Karila, L., Zarmdini, R., Petit, A., Lafaye, G., Lowenstein, W. y Reynaud, M. (2014). Cocaine addiction: Current data for clinician. Presse Medicale 43, 9-17.
  • Kessler, R. C., Crum, R. M., Warner, L. A., Nelson, C. B., Schulenberg, J. y Anthony, J. C. (1997). Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry, 54,313-321.
  • Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Delmer, O.,… Zaslavsky, A. M. (2006). The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication. American Journal of Psychiatry, 163, 716-723.
  • Kessler, R. C. y Ustün, T. B. (2004). The word mental health (WMH) survey initiative version of the world health organization (WHO) composite international diagnostic interview (CIDI). International Journal of Methods in Psychiatric Research, 13, 93-121.
  • Keyes, K. M., Martins, S. S., Blanco, C. y Hasin D. S. (2010). Telescoping and gender differences in alcohol dependence: new evidence from two national surveys. American Journal Psychiatry, 167, 969-976. doi: 10.1176/appi.ajp.2009.09081161.
  • Kinsey, S. G., O’Neal, S. T., Long, J. Z., Cravatt, B. F. y Lichtman, A. H. (2011). Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like in the marble burying assay. Pharmacology Biochemistry and Behavior, 98, 21-27. doi: 10.1016/j.pbb.2010.12.002.
  • Malinen, H., Lehtonen, M. y Hyytiä, P. (2009). Modulation of brain endocannabinoid levels by voluntary alcohol consumption in alcohol-preferring AA rats. Alcoholism: Clinical and Experimental Research, 33, 1711-1720. doi: 10.1111/j.1530-0277.2009.01008.x.
  • Morguello, S., Holzer, C.E., Ryan, E., Young, C., Naseer, M., Castellon, S. A.,… Singer, E. J. (2006). Interrater reliability of the Psychiatric Research Interview for Substance and mental Disorders in an HIV-infected cohort: experience of the National NeuroAIDS Tissue Consortium. International Journal of Methods in Psychiatric Research, 15, 131-138.
  • Navarro, M., Hernández, E., Muñoz, R. M., del Arco, I., Villanúa, M. A., Carrera, M. R. y Rodríguez de Fonseca, F. (1997). Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat. Neuroreport, 8, 491-496.
  • Observatorio Español sobre Drogas (2013). Encuesta Domiciliaria sobre Alcohol y Drogas en España (EDADES) 2011-2012.
  • Pavón, F. J., Araos, P., Pastor, A., Calado, M., Pedraz, M., Campos-Cloute, R.,… Rodríguez de Fonseca, F. (2013). Evaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity. Addiction Biology, 18, 955-969. doi: 10.1111/adb.12107.
  • Pedraz, M., Araos, P., García-Marchena, N., Serrano, A., Romero-Sanchiz, P, Suárez, J.,… Pavón, F.J. (2015). Sex differences in psychiatric comorbidity and plasma biomakers for cocaine addiction in abstinent cocaine-addicted subjects in outpatient settings. Frontiers in Psychiatry, 16, 6-17. doi: 10.3389/fpsyt.2015.00017.
  • Pérez-Gálvez, B., de Vicente-Manzanaro, M. P., García-Fernández, L., Romero-Escobar, C. y Oliveras-Valenzuela, M. A. (2008). Prevalencia de psicopatología en dependientes al alcohol en tratamiento ambulatorio. Trastornos Adictivos, 10, 42-48.
  • Piomelli, D. (2003). The molecular logic of endocannabinoid signalling. Nature Reviews Neuroscience, 4, 873-884.
  • Polanczyk, G. V., Willcut, E. G., Salum, G. A., Kieling, C. y Rohde, L. A. (2014). ADHD prevalence estimates across three decades: an updated systematic review and meta-regression analysis. International Journal of Epidemiology, 43, 434-442. doi: 10.1093/ije/dyt261.
  • Ponce, G., Rodríguez-Jiménez, R., Rojo, J.A., Sánchez-Monasor, R. y Rubio, G. (2000). Attention-defict hyperactivity disorder and vulnerability to the development of alcoholism: use of the Wender-Utah Rating Scale for retrospective diagnostic of ADHD in the childhood of alcoholic patients. Actas Españolas de Psiquiatría, 28, 357-366.
  • Quintero, J., Balanzá-Martínez, V., Correas, J. y Soler, B. (2013). Attention Deficit Hyperactivity Disorder (ADHD) in the adult patients: view of the clinician. Actas Españolas de Psiquiatría, 41, 185-195.
  • Robins, L. N., Wing, J., Wittchen, H. U., Helzer, J. E., Babor, T. F., Burke, J.,… Towle, L. H. (1988). The Composite International Diagnostic Interview: an epidemiologic instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Archives of General Psychiatry, 45, 1069-1077.
  • Rodríguez-Jiménez, R., Ponce, G., Monasor, R., Jiménez-Giménez, M., Pérez-Rojo, J.A. y Rubio, G. (2001). Validación en población española adulta de la Wender-Utah Rating Scale para la evaluación retrospectiva de trastorno por déficit de atención e hiperactividad en la infancia. Revista de Neurología, 33,44.
  • Rodriguez-Jimenez, R., Aragües, M., Jiménez-Arriero, M. A., Ponce, G., Muñoz, A., Bagney, A.,… Palomo, T. (2008). Dual diagnosis in psychiatric inpatients: prevalence and general characteristics. Investigacion Clínica, 49, 195-205.
  • Ross, H. E. (1995). DSM-III-R alcohol abuse and dependence and psychiatric comorbidity in Ontario: results from the Mental Health Supplement to the Ontario Health Survey. Drug and Alcohol Dependence, 39, 111-128.
  • Ruffles, G. (2009). Emergency care for young people who have used cocaine. Emergency Nurse, 17,34-36. doi: http://dx.doi.org/10.7748/en2009.12.17.8.34.c7433
  • Salom, C. L., Betts, K. S., Williams, G. N., Najman, J. N., Scott, J. G. y Alati, R. (2014). Do young people with comorbid mental and alcohol disorders experience worse behavioral problems?. Psychiatry Research. 219, 372-379. doi: 10.1016/j.psychres.2014.05.056.
  • Samet, S., Fenton, M., Nunes, E., Greenstein, E., Aharonovich, E. y Hasin, D. (2013). Effects of independent and substance-induced major depressive disorder on remission and relapse of alcohol, cocaine and heroin dependence. Addiction, 108, 115-123. doi: 10.1111/j.1360-0443.2012.04010.x.
  • Serrano, A., Rivera, P., Pavón, F. J., Decara, J., Suárez, J., Rodríguez de Fonseca F. y Parsons L. H. (2012). Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala. Alcoholism: Clinical and Experimental Research 36, 984-994. doi: 10.1111/j.1530-0277.2011.01686.x.
  • Tómasson, K. y Vaglum, P. (1995). A nationwide representative sample of treatment seeking alcoholics: A study of psychiatric comorbidity. Acta Psychiatrica Scandinavica, 92,378–385.
  • Torrens, M., Serrano, D., Astals, M., Pérez-Domíngez, G. y Martín-Santos, R. (2004). Diagnosis comorbid psychiatric disorders in substance abusers: validity of the Spanish versions of the Psychiatric Research Interview for Substance and Mental Disorders and the Structured Clinical Interview for DSM-IV. American Journal Psychiatry, 161,1231-1237.
  • Torrens, M., Gilchrist, G., y Domingo-Salvany, A. y psyCoBarcelona Group (2011). Psychiatric comorbidity in illicit drug users: Substance-induced versus independent disorders. Drug and Alcohol Dependence. 133, 147-156. doi: 10.1016/j.drugalcdep.2010.07.013.
  • Vergara-Moragues, E., González-Saiz, F., Lozano, O. M., Betanzos Espinosa, P., Fernández Calderón, F., Bilbao-Acebos, I.,… Verdejo García, A. (2012). Psychiatric comorbidity in cocaine users treated in therapeutic community. Substance induced versus independent disorders. Psychiatry Research, 200, 734-741. doi: 10.1016/j.psychres.2012.07.043.
  • World Health Organization (2014). Global status report on alcohol and health-2014. World Health Organization.
Fonte de datos: Dialnet