Liquid biopsycirculating tumor cells utility in precision medicine
- Clotilde Costa Nogueira Director
- Laura Muinelo Romay Co-director
Universidade de defensa: Universidade de Santiago de Compostela
Fecha de defensa: 02 de xullo de 2019
- Joan Albanell Mestres Presidente/a
- Manuel Collado Rodríguez Secretario
- Gema Moreno Bueno Vogal
Tipo: Tese
Resumo
Metastatic disease is the leading cause of cancer associated deaths. Circulating tumour cells (CTCs) are responsible for tumoral dissemination, as they are able to be released from the primary tumour and establish distal metastatic foci. The objective of this doctoral thesis is to increase the knowledge of CTCs, through the use of liquid biopsy. To this aim, with the use of blood samples from metastatic cancer patients we identified key biomarkers for cancer progression. In this context, different experimental approaches were considered: the validation of new technologies for the study of CTCs, the isolation and molecular analysis of CTCs and the establishment of in vivo models.