Amisulpride en el tratamiento de la dependencia alcohólica

  1. Flórez Menéndez, Gerardo
  2. Saiz Martínez, Pilar Alejandra
  3. García Portilla González, María Paz
  4. Álvarez González, Sandra
  5. Nogueiras Fernández, Luis
  6. Bobes García, Julio
Journal:
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Year of publication: 2011

Volume: 23

Issue: 2

Pages: 149-156

Type: Article

DOI: 10.20882/ADICCIONES.158 DIALNET GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Adicciones: Revista de socidrogalcohol

Sustainable development goals

Abstract

Objetivos: Estudio abierto, naturalístico de 6 meses de seguimiento, para comparar la eficacia de amisulpride frente a topiramato y naltrexona en pacientes con dependencia al alcohol. Métodos: se han incluido un total de 274 pacientes diagnosticados de dependencia al alcohol y con un consumo intenso de alcohol durante el último mes. Una vez desintoxicados los pacientes fueron asignados a diferentes grupos de tratamiento (naltrexona a 50 mgr por día, topiramato a 200 mgr por día o amisulpride a 100 mgr por día). Dichos pacientes fueron evaluados al inicio del tratamiento y a los 3 y 6 meses de seguimiento mediante instrumentos para medir el consumo de alcohol (EuropASI y Alcohol Timeline Followback), el craving (OCDS), la discapacidad (WHO/DAS) y la calidad de vida (EQ-5D); también se utilizaron marcadores biológicos de consumo de alcohol. Resultados: a los 6 meses los pacientes que tomaban amisulpride obtenían peores resultados en variables relacionadas directamente con el consumo de alcohol (OCDS, alcohol consumido, número de bebidas por día de consumo y días de consumo intenso), sin embargo no se encontraron diferencias significativas en esas variables al compararse con naltrexona. Conclusiones: en este estudio, amisulpride, a dosis de 100 mgr por día, fue menos eficaz que topiramato, a dosis de 200 mgr por día, pero demostró eficacia similar a la naltrexona, a dosis de 50 mgr por día, a la hora de reducir el consumo de alcohol y el craving.

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