Eficiencia de diversas estrategias para el diagnóstico de la hepatitis C en un solo paso

  1. Javier Crespo 1
  2. José María Eiros Bouza 2
  3. Antonio Javier Blasco Bravo
  4. Pablo Lázaro de Mercado
  5. Antonio Aguilera Guirao 3
  6. Federico García 4
  7. Javier García-Samaniego Rey 5
  8. José Luis Calleja Panero 6
  1. 1 Hospital Universitario Marqués de Valdecilla
    info
    Hospital Universitario Marqués de Valdecilla

    Santander, España

    ROR https://ror.org/01w4yqf75

    Localización xeográfica da organización Hospital Universitario Marqués de Valdecilla
  2. 2 Hospital Universitario Pío del Río Hortega
    info
    Hospital Universitario Pío del Río Hortega

    Valladolid, España

    ROR https://ror.org/05jk45963

    Localización xeográfica da organización Hospital Universitario Pío del Río Hortega
  3. 3 Complexo Hospitalario Universitario de Santiago
    info
    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

    Localización xeográfica da organización Complexo Hospitalario Universitario de Santiago
  4. 4 Hospital Universitario San Cecilio.Granada
  5. 5 Hospital Universitario La Paz
    info
    Hospital Universitario La Paz

    Madrid, España

    ROR https://ror.org/01s1q0w69

    Localización xeográfica da organización Hospital Universitario La Paz
  6. 6 Hospital Universitario Puerta de Hierro
    info
    Hospital Universitario Puerta de Hierro

    Madrid, España

    ROR https://ror.org/01e57nb43

    Localización xeográfica da organización Hospital Universitario Puerta de Hierro
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Revista:
Revista Española de Enfermedades Digestivas

ISSN: 2340-4167,  1130-0108

Ano de publicación: 2019

Volume: 111

Número: 1

Páxinas: 10-16

Tipo: Artigo

DOI: 10.17235/REED.2018.5810/2018 DIALNET GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Revista Española de Enfermedades Digestivas

Obxectivos de Desenvolvemento Sustentable

Resumo

Background: implementing one-step strategies for hepatitis C diagnosis would help shorten the time to treatment access. Thus avoiding disease progression and complications, while facilitating hepatitis C virus (HCV) elimination. Objective: to assess the validity and certainty of potential one-step strategies for the diagnosis of HCV infection and their associated cost and efficiency. Methods: the study design is an economic appraisal of efficiency (cost/efficacy) using decision trees and deterministic sensitivity analysis. The analysis was performed from the payer perspective (Spanish National Health System), which exclusively considers the direct costs. Only the differential costs (diagnostic testing costs) were taken into account and the study was set in Spain. The efficacy of a diagnostic strategy was defined as the percentage of patients with an active HCV infection who received a positive diagnosis and the efficiency was defined as the cost per patient with a correctly diagnosed and active infection. Results: the one-step strategies evaluated for the diagnosis of HCV had an acceptable validity and certainty due to the high sensitivity and specificity of the considered tests. The Ab-Ag strategy was the most efficient, followed by Ab-Ag-VL and Ab-VL. Ab-Ag was the most efficient due to the lower cost per patient tested, although the efficacy was lower than the Ab-VL efficacy. Conclusion: the study findings may help to establish more appropriate one-step diagnostic approaches whilst considering the efficacy and efficiency.

Fonte de datos: Dialnet