Características clínicas, manejo y resultados de los pacientes con endoftalmitis estéril asociados con la inyección intravítrea de factores de crecimiento endotelial antivascular

  1. M. Gil-Martínez 14
  2. M.J. Rodríguez-Cid 1
  3. M.I. Fenández-Rodriguez 14
  4. M.J. Blanco-Teijero 1
  5. M.J. Abraldes 14
  6. E. Bandín Vilar 23
  7. I. Zarra-Ferro 23
  8. M. González-Barcia 23
  9. F. Gómez-Ulla 4
  10. A. Fernández-Ferreiro 23
  1. 1 Hospital de Conxo
    info

    Hospital de Conxo

    Santiago de Compostela, España

  2. 2 Departamento Farmacia, Xerencia de Xestión Integrada de Santiago de Compostela, SERGAS, Santiago de Compostela, La Coruña, Spain
  3. 3 Instituto de Investigación Sanitaria de Santiago de Compostela
    info

    Instituto de Investigación Sanitaria de Santiago de Compostela

    Santiago de Compostela, España

  4. 4 Instituto Oftalmológico Gómez-Ulla, Santiago de Compostela, La Coruña, Spain
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Journal:
Archivos de la Sociedad Española de Oftalmologia

ISSN: 0365-6691

Year of publication: 2020

Volume: 95

Issue: 5

Pages: 211-216

Type: Article

DOI: 10.1016/J.OFTAL.2020.01.019 DIALNET GOOGLE SCHOLAR

More publications in: Archivos de la Sociedad Española de Oftalmologia

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Abstract

Purpose Analyze clinical features, management and outcomes of patients with sterile endophthalmitis associated with intravitreal antivascular endothelial growth factor. Methods Observational retrospective case series of patients with sterile endophthalmitis following anti-VEGF intravitreal injections. Clinical data of patients treated with intravitreal anti-VEGFs during one year have been revised. Those who have presented an episode of sterile endophthalmitis are analyzed and their causality and management are studied. Results Seven patients have had a sterile endophthalmitis onset within 4 days after intravitreal injection (aflibercept n = 5 and ranibizumab n = 2). These patients have some active neovascular condition: age related macular degeneration (n = 4), myopic choroidal neovascularization (n = 1) or macular edema: diabetic macular edema (n = 1), branch retinal vein occlusion (n = 1). Shared signs and symptoms included painless vision loss, anterior chamber and vitreous cell and lack of hypopyon. In all patients, visual acuity returned to within one line of baseline acuity. Conclusion Differentiating cases of sterile from infectious endophthalmitis may be challenging. It is crucial to differentiate both entities as a good diagnosis determines the visual prognosis. We should be aware of minimal inflammation after repeated intravitreal injections in order to establish the adequate treatment.

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