Factores asociados al riesgo cardiovascular y enfermedad cardiovascular y renal en el estudio IBERICAN (Identificación de la poBlación Española de RIesgo CArdiovascular y reNal)resultados definitivos

  1. S. Cinza-Sanjurjo 1
  2. R.M. Micó-Pérez 2
  3. S. Velilla-Zancada 3
  4. M.A. Prieto-Díaz 4
  5. G.C. Rodríguez-Roca 5
  6. A. Barquilla García 6
  7. J. Polo García 7
  8. V. Martín Sánchez 8
  9. J.L. Llisterri Caro 9
  1. 1 Centro de Salud de Porto do Son, AS Santiago de Compostela, Porto do Son, A Coruña, España
  2. 2 Centro de Salud de Fontanars dels Alforins, EAP Ontinyent, Fontanars dels Alforins, Valencia, España
  3. 3 Centro de Salud Joaquín Elizalde, Logroño, España
  4. 4 Centro de Salud Vallobín-La Florida, Oviedo, España
  5. 5 Centro de Salud de Puebla de Montalbán, La Puebla de Montalbán, Toledo, España
  6. 6 Centro de Salud de Trujillo, Trujillo, Cáceres, España
  7. 7 Centro de Salud Casar de Cáceres, Casar de Cáceres, Cáceres, España
  8. 8 Instituto de Biomedicina (IBIOMED), Universidad de León, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), León, España
  9. 9 Fundación Sociedad Española de Médicos de Atención Primaria, Semergen, Madrid, España
Journal:
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Year of publication: 2020

Issue: 6

Pages: 368-378

Type: Article

DOI: 10.1016/J.SEMERG.2020.06.027 DIALNET GOOGLE SCHOLAR

More publications in: Semergen: revista española de medicina de familia

Abstract

Objective To analyse the prevalence in clinical practice of cardiovascular risk factors (CVRF) and cardiovascular disease (CVD), as well as their causal relationship, in the study inclusion visit. Material and methods Cross-sectional analysis of the study inclusion visit of 8,066 patients of 18 to 85 years of age included in the IBERICAN study. By reviewing the medical history, analytics and medical visits, the patient's physician has collected socio-demographic information, personal and family history and prevalence of CVRF and CVD and renal disease. A multivariate analysis was carried out using a logistic regression that included the autonomous region variable as a random effect variable, in order to analyse the impact of certain variables on the development of each CVRF, metabolic syndrome, subclinical organ damage, renal disease, and CVD. Results Dyslipidaemia was 2.4 times more frequent in diabetics, and the risk was increased by 59% in hypertensive patients. Arterial hypertension was twice as frequent in diabetics, and increased 94% in hyperuricaemic patients and 62.1% in dyslipidaemia patients. Diabetes mellitus was 2.5 times higher in dyslipidaemia patients, and 2.2 times higher in hypertensive patients. CVD was four times more frequent in patients with a family history, and the risk in women was increased by 90.8% and by 53.8% in patients with renal disease. Conclusions The Spanish population seen in Primary Care that were analysed in the IBERICAN study had a high prevalence of CVRF and CVD, which gives it a high CVR. The multivariate analysis performed shows a close causal relationship between the CVRF with each other, and with renal disease and CVD.

Funding information

A la Fundaci?n SEMERGEN por la financiaci?n del estudio, a los investigadores que han participado activamente en el reclutamiento de los pacientes y a los pacientes por su participaci?n.

Bibliographic References

  • Instituto Nacional de Estadística. Defunciones según la causa de muerte. Año 2016. Nota de prensa publicada 19/12/2018 [consultado 19 Mar 2019]. Disponible en: https://www.ine.es/prensa/edcm_2017.pdf Google Scholar
  • European Core Health Indicators, 2017 [consultado 19 Nov 2019]. Disponible en: http://ec.europa.eu/health/dyna/echi/datatool/index.cfm?indlist=13 Google Scholar
  • J.B. Soriano, D. Rojas-Rueda, J. Alonso, J.M. Antó, P.J. Cardona, E. Fernández, et al., Colaboradores de GBD en España The burden of disease in Spain: Results from the Global Burden of Disease 2016 Med Clin (Barc)., 151 (2018), pp. 171-190 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • M. O’Flaherty, I. Buchan, S. Capewell Contributions of treatment and lifestyle to declining CVD mortality: Why have CVD mortality rates declined so much since the 1960s? Heart., 99 (2013), pp. 159-162 CrossRefView Record in ScopusGoogle Scholar
  • Ministerio de Sanidad, Consumo y Bienestar Social. Encuesta Nacional de Salud. España 2017. 26 Jun 2018 [consultado 19 Mar 2019]. Disponible en: https://www.mscbs.gob.es/estadEstudios/estadisticas/encuestaNacional/encuestaNac2017/ENSE2017_notatecnica.pdf Google Scholar
  • F. Villar, J.R. Banegas, J. Donado, F. Rodríguez Artalejo Las enfermedades cardiovasculares y sus factores de riesgo en España: hechos y cifras. Informe SEA 2007 Sociedad Española de Arteriosclerosis;, Madrid (2007) Google Scholar
  • V. Dzau, E. Braunwald Resolved and unresolved issues in the prevention and treatment of coronary artery disease: A workshop consensus statement Am Heart J., 121 (1991), pp. 1244-1263 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • S. Cinza Sanjurjo, V. Martín Sánchez, M.A. Prieto Díaz, A. Barquilla García, J. Polo García, S. Velilla Zancada, et al. Descripción de la muestra, diseño y métodos del estudio para la identificación de la población española de riesgo cardiovascular y renal (IBERICAN) Semergen., 46 (2019), pp. 4-15, 10.1016/j.semerg.2019.10.006 Google Scholar
  • M.F. Piepoli, A.W. Hoes, S. Agewall, C. Albus, C. Brotons, A.L. Catapano, et al., Task Force Members 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR) Eur Heart J., 37 (2016), pp. 2315-2381 CrossRefView Record in ScopusGoogle Scholar
  • J.C. Kovacic, P. Moreno, V. Hachinski, E.G. Nabel, V. Fuster Cellular senescence, vascular disease, and aging: Part 1 of a 2-part review Circulation., 123 (2011), pp. 1650-1660 View Record in ScopusGoogle Scholar
  • P. Libby, P. Ridker, A. Maseri Inflammation and atherosclerosis Circulation., 105 (2002), pp. 1135-1143 View Record in ScopusGoogle Scholar
  • H.U. Wittchen, H. Glaesmer, W. März, G. Stalla, H. Lehnert, A.M. Zeiher, et al., DETECT-Study Group Cardiovascular risk factors in primary care: Methods and baseline prevalence rates-the DETECT program Curr Med Res Opin., 21 (2005), pp. 619-630 CrossRefView Record in ScopusGoogle Scholar
  • A. Ruiz-García, E. Arranz-Martínez, J.C. García-Álvarez, L.E. Morales-Cobos, M.E. García-Fernández, N. de la Peña-Antón, et al., en nombre del Grupo de investigación del Estudio SIMETAP Población y metodología del estudio SIMETAP: Prevalencia de factores de riesgo cardiovascular, enfermedades cardiovasculares y enfermedades metabólicas relacionadas Clin Investig Arterioscler., 30 (2018), pp. 197-208 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • L. Palomo, J.L. Félix-Redondo, L. Lozano-Mera, J.F. Pérez-Castán, D. Férnandez-Bergés, F. Buitrago Cardiovascular risk factors, lifestyle, and social determinants: A cross-sectional population study Br J Gen Pract., 64 (2014), pp. e627-e633, 10.3399/bjgp14X681793 View Record in ScopusGoogle Scholar
  • U. Bilal, J. Diez, S. Alfayate, P. Gullón, I. del Cura, F. Escobar, et al. Population cardiovascular health and urban enviroments: The Heart Healthy Hoods exploratory study in Madrid, Spain BMC Med Res Methodol., 16 (2016), p. 104, 10.1186/s12874-016-0213-4 Google Scholar
  • J.D. Spence, L. Pilote Importance of sex and gender in atherosclerosis and cardiovascular disease Atherosclerosis., 241 (2015), pp. 208-210 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • R. Hausmann, L.D. Tyson, Y. Bekhouche, S. Zahidi The Global Gender Gap Report (2012), p. 2015 [consultado 22 Ene 2020]. Disponible en: http://www3.weforum.org/docs/GGGR12/MainChapter_GGGR12.pdf
  • Y. Shen, R. Cai, J. Sun, X. Dong, R. Huang, S. Tian, et al. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: A systematic review and meta-analysis Endocrine., 55 (2017), pp. 66-76 CrossRefView Record in ScopusGoogle Scholar
  • L. Cea-Calvo, B. Moreno, S. Monereo, V. Gil-Guillén, J.V. Lozano, J.C. Martí-Canales, et al. Prevalencia de sobrepeso y obesidad en población española de 60 años o más y factores relacionados. Estudio PREV-ICTUS Med Clin (Barc)., 131 (2008), pp. 205-210 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
  • N. Dich, J. Head, N. Hulvej Rod Role of psychosocial work factors in the relation between becoming a caregiver and changes in health behaviour: Results from the Whitehall II cohort study J Epidemiol Community Health., 70 (2016), pp. 1200-1206, 10.1136/jech-2015-206463 CrossRefView Record in ScopusGoogle Scholar
  • R.A.H. Stewart, C. Held, S. Krug-Gourley, D. Waterworth, A. Stebbins, K. Chiswell, et al. Cardiovascular and lifestyle risk factors and cognitive function in patients with stable coronary heart disease J Am Heart Assoc., 8 (2019), p. e010641 Google Scholar
  • H.J. Schneider, N. Friedrich, J. Klotsche, L. Pieper, M. Nauck, U. John, et al. The predictive value of different measures of obesity for incident cardiovascular events and mortality J Clin Endocrinol Metab., 95 (2010), pp. 1777-1785 CrossRefView Record in ScopusGoogle Scholar
  • J. Cosín Aguilar, A. Hernándiz Martínez, X. Masramón Morell, R. Arístegui Urrestarazu, A. Aguilar Llopis, J.L. Zamorano Gómez, et al. Overweight and obesity in hypertensive Spanish patients. The CORONARIA study Med Clin (Barc)., 129 (2007), pp. 641-645 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
  • D.B. Panagiotakos, C. Pitsavos, C. Stefanadis Dietary patterns: A Mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk Nutr Metab Cardiovasc Dis., 16 (2006), pp. 559-568 ArticleDownload PDFView Record in ScopusGoogle Scholar
  • R. Estruch, E. Ros, J. Salas-Salvadó, M.I. Covas, D. Corella, F. Arós, et al., PREDIMED Study Investigators Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts N Engl J Med., 378 (2018), p. e34 Google Scholar
  • A. Pandey, U. Salahuddin, S. Garg, C. Ayers, J. Kulinski, V. Anand, et al. Continuous dose-response association between sedentary time and risk for cardiovascular disease: A meta-analysis JAMA Cardiol., 1 (2016), pp. 575-583 CrossRefView Record in ScopusGoogle Scholar
  • J. Redon, M. Tellez-Plaza, D. Orozco-Beltran, V. Gil-Guillen, S. Pita Fernandez, J. Navarro-Pérez, et al., ESCARVAL Study Group Impact of hypertension on mortality and cardiovascular disease burden in patients with cardiovascular risk factors from a general practice setting: The ESCARVAL-risk study J Hypertens., 34 (2016), pp. 1075-1083 View Record in ScopusGoogle Scholar
  • J. Navarro-Pérez, D. Orozco-Beltran, V. Gil-Guillen, V. Pallares, F. Valls, A. Fernandez, et al., ESCARVAL Study Group Mortality and cardiovascular disease burden of uncontrolled diabetes in a registry-based cohort: The ESCARVAL-risk study BMC Cardiovasc Disord., 18 (2018), p. 180 Google Scholar
  • J. Cosín Aguilar, L. Rodríguez Padial, A. Hernándiz Martínez, R. Arístegui Urrestarazu, X. Masramón Morell, B. Armada Peláez, et al. Cardiovascular risk in diabetes mellitus and hypertension in Spain. The CORONARIA study Med Clin (Barc)., 127 (2006), pp. 126-132 ArticleDownload PDFCrossRefView Record in ScopusGoogle Scholar
  • M. Tellez-Plaza, D. Orozco-Beltran, V. Gil-Guillen, S. Pita-Fernandez, J. Navarro-Pérez, V. Pallares, et al., ESCARVAL Study Group Renal function and attributable risk of death and cardiovascular hospitalization in patients with cardiovascular risk factors from a registry-based cohort: The Estudio Cardiovascular Valencia-risk study J Hypertens., 34 (2016), pp. 2266-2273 View Record in ScopusGoogle Scholar