Abatacept en pacientes con artritis reumatoide y enfermedad pulmonar intersticial

Resumo

Retrospective open multicenter study of 263 patients with rheumatoid arthritis and interstitial lung disease (RA-ILD) treated with at least 1 dose of ABA. ILD was diagnosed by HRCT. Treatment efficacy was evaluated using the following variables: a) Changes on Modified Medical Research Council (MMRC) ≥ 1; b) Improvement or worsening of forced vital capacity (FVC) and / or DLCO ≥10%; c) qualitative HRCT modifications d) change in DAS28, e) Mean prednisone dose. Values were collected at 0, 3, 6, 12 months and then once every 12 up to a maximum of 60 months. A subgroup analysis was also performed to assess the influence of the pulmonary pattern and combined treatment with DMARDs. ABA is presented in our study as an effective and relatively safe alternative in the treatment of RA-ILD regardless of the pattern of involvement and our data suggest that ABA plus methotrexate may be a safe combination and help to sparring. These data must be corroborated in clinical trials.