Research and development of advanced controlled drug delivery systemsapplication in Keratoconus and Leber´s Hereditary Optic Neuropathy

  1. Varela Fernández, Rubén
Dirixida por:
  1. Francisco Javier Otero Espinar Director
  2. Isabel Lema Gesto Director
  3. Miguel González Barcia Director

Universidade de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 27 de xuño de 2022

  1. José Blanco Méndez Presidente
  2. Maria Aranzazu Acera Osa Secretario/a
  3. Alicia C. López Castellano Vogal

Tipo: Tese


In the present thesis, the research, development, and characterization processes of controlled drug delivery systems intended for the treatment of two different ocular pathologies were described. Firstly, different types of lactoferrin-loaded nanoparticles intended for topical ophthalmic administration were developed and proposed as the first pharmacological alternative for the Keratoconus (KC) treatment. On the other hand, idebenone-loaded polymeric implants and microparticles were designed and proposed as new therapeutic strategies for the treatment of Leber's Hereditary Optic Neuropathy (LHON).