Papel de las adaptaciones epigenéticas en el riesgo de enfermedades cardiovasculares en la población latinoamericana

  1. López-Jaramillo, Patricio 1
  2. Cohen, Daniel 2
  3. Velandia, Carlos 1
  4. Sotomayor-Rubio, Arístides 3
  5. Rincón-Romero, Katherine 4
  6. López-López, José 3
  7. Gómez Arbeláez, Diego 4
  1. 1 Foscal Hospital
    info

    Foscal Hospital

    Floridablanca, Colombia

    ROR https://ror.org/04wnzzd87

  2. 2 London Metropolitan University
    info

    London Metropolitan University

    Londres, Reino Unido

    ROR https://ror.org/00ae33288

  3. 3 Universidad Autónoma de Bucaramanga
    info

    Universidad Autónoma de Bucaramanga

    Bucaramanga, Colombia

    ROR https://ror.org/00gkhpw57

  4. 4 Universidad de Santander
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Revista:
Revista Med de la Facultad de Medicina

ISSN: 1909-7700,  0121-5256

Ano de publicación: 2011

Volume: 19

Número: 1

Tipo: Artigo

DOI: 10.18359/RMED.1220 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Outras publicacións en: Revista Med de la Facultad de Medicina

Obxectivos de Desenvolvemento Sustentable

Resumo

Las enfermedades cardio-metabólicas (obesidad, diabetes mellitus tipo 2, infarto agudo de miocardio y accidente cerebro-vascular) son al momento el problema de salud pública más relevante en Colombia. La rápida urbanización experimentada por el país en los últimos 50 años, así como los cambios en los hábitos nutricionales y en la actividad física asociada a la urbanización han determinado que en el proceso de adaptación biológica de la población colombiana a este rápido proceso medioambiental, se sobre expresen por vía epigenética, substancias pro inflamatorias y aquellas que llevan a resistencia a la insulina, mecanismo que confiere una mayor susceptibilidad para que nuestra población desarrolle las enfermedades cardio-metabólicas. Este proceso es especialmente grave en los niños escolares de nuestras ciudades. De frente a esta situación, en el presente artículo revisamos una serie de evidencias que nos llevan a proponer que el ejercicio, especialmente el de fuerza puede, vía epigenética, determinar un mayor desarrollo de masa muscular y la expresión de sustancias producidas en el músculo que tienen propiedades anti inflamatorias y que mejoran la sensibilidad a la insulina, por lo cual se contraponen al estado de resistencia a la insulina y a la inflamación de bajo grado, producto de la obesidad especialmente abdominal.

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Fonte de datos: Dialnet