Cáncer de ovario

  1. Pérez Martelo, M. 1
  2. Cebey López, V. 1
  3. Mateos González, M. 1
  4. Cueva Bañuelos, J.F. 1
  1. 1 Servicio de Oncología Médica y Grupo de Oncología Médica Traslacional, Hospital Clínico Universitario e Instituto de Investigación Sanitaria-CIBERONC, Santiago de Compostela, La Coruña, España
Revista:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Ano de publicación: 2021

Título do exemplar: Enfermedades oncológicas (IV)Melanoma, cáncer de mama y tumores ginecológicos

Serie: 13

Número: 27

Páxinas: 1518-1526

Tipo: Artigo

DOI: 10.1016/J.MED.2021.03.003 DIALNET GOOGLE SCHOLAR

Outras publicacións en: Medicine: Programa de Formación Médica Continuada Acreditado

Obxectivos de Desenvolvemento Sustentable

Resumo

El cáncer de ovario es la segunda neoplasia ginecológica más común y la que produce mayor mortalidad. El carcinoma seroso de alto grado es el subtipo histológico más frecuente. Su presentación clínica suele ser insidiosa, de modo que la mayoría de las veces el diagnóstico se realiza con la enfermedad avanzada intraabdominal. La estadificación quirúrgica y la cirugía citorreductora primaria realizada por un equipo experimentado seguida de quimioterapia adyuvante basada en platino y taxano es el enfoque terapéutico más utilizado, especialmente en los casos más precoces. En ocasiones, sobre todo en la enfermedad avanzada, la quimioterapia se administra previa a una cirugía de intervalo. La mayoría de las pacientes en etapa avanzada recaerán y requerirán tratamiento adicional. Además de la quimioterapia basada en platino y taxano, nuevos fármacos como bevacizumab y especialmente los inhibidores de PARP han venido a mejorar los resultados, siendo estos especialmente eficaces en presencia de mutaciones en BRCA, tanto en la primera línea de tratamiento como en la recaída.

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Fonte de datos: Dialnet