Epigenomic characterization of circulating tumour cells in advanced colorectal cancer

  1. Aida Bao Camaño
Dirigida por:
  1. Angel Diaz Lagares Director
  2. Rafael López López Director

Universidad de defensa: Universidade de Santiago de Compostela

Fecha de defensa: 09 de mayo de 2023

Tribunal:
  1. Jesús García-Foncillas López Presidente/a
  2. Roberto Piñeiro Cid Secretario
  3. Evi S. Lianidou Vocal

Tipo: Tesis

Resumen

Metastatic colorectal cancer continues to be a major health burden despite advances in detection and therapy. Molecular characterization of circulating tumour cells (CTCs), main drivers of the metastatic process, and the study of epigenetic mechanisms hold great promise to identify new targets for drug development and biomarkers to assess therapy response. In this frame, this thesis characterized the DNA methylome of CTCs in advanced colorectal cancer, providing new information about the biology of these cells and the metastatic process. This study also identified new potential therapeutic targets and epigenetic biomarkers that could help guide therapeutic decisions in patients with advanced disease, contributing to achieve a more personalized medicine in colorectal cancer.