Aprendizaje y memoria verbalcomparación entre pacientes con trastorno por consumo de alcohol y trastorno de depresión mayor

  1. Rocio Villa Diez 1
  2. Julia Rodríguez-Revuelta 1
  3. Ashkan Espandian 2
  4. Isabel Menéndez-Miranda 1
  5. Francesco Dal Santo 1
  6. María Paz García-Portilla 1
  7. Gerardo Flórez 3
  8. Julio Bobes 1
  9. Pilar Alejandra Sáiz Martínez 1
  1. 1 Servicio de Salud del Principado de Asturias (SESPA), España
  2. 2 Servicio de Psiquiatría del Hospital del Bierzo. Servicio de Salud Mental de Castilla y León (SACYL), España
  3. 3 Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), España
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Revista:
Adicciones: Revista de socidrogalcohol

ISSN: 0214-4840

Ano de publicación: 2024

Volume: 36

Número: 1

Páxinas: 21-30

Tipo: Artigo

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Outras publicacións en: Adicciones: Revista de socidrogalcohol

Resumo

Brain damage related to alcohol consumption is associated with impairments in cognitive functions, among which memory and verbal learning stand out. The main objective is to evaluate memory and verbal learning in a sample of 111 patients with alcohol use disorder (AUD) versus 78 with major depressive disorder (MDD) and 100 healthy controls. The evaluation included sociodemographic and clinical variables, the Hamilton Depression Scale (HDRS) and the California Verbal Learning Test (CVLT). One-way ANOVA was used for comparisons between the 3 groups and two-way ANCOVAS including different covariates. The one-way ANOVA shows that patients with AUD and MDD had scores similar to each other and lower than those of the control group (p <0.001), with the exception of the Cued CVLT (worse scores in MDD vs AUD, p <0.001). After including age, sex and years of completed studies as covariates, the differences between the AUD and MDD groups persisted compared to the control group (p ≤ 0.003) in all indices except for the Immediate Free CVLT and the Cued CVLT (worse performance in MDD vs AUD, p = 0.022 and p = 0.035, respectively). In the second ANCOVA, after controlling for depression severity, differences were only detected between AUD patients and healthy controls (p ≤ 0.007). Patients with AUD present a significant impairment in learning and verbal memory when compared with patients with MDD and with healthy people.

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