Utilidad de la interleukina-6 y de la proteína C reactiva ultrasensible como marcadores pronósticos en pacientes ambulatorios con insuficiencia cardíaca y fracción de eyección reducida

  1. Chirino Navarta, Daniel Agustín; Servicio de Cardiología de la Unidad Asistencial Por Más Salud Dr. César Milstein, Ciudad Autónoma de Buenos Aires; Servicio de Cardiología del Sanatorio Franchín, Ciudad Autónoma de Buenos Aires; 1
  2. Trejo, Graciela 2
  3. Leonardi, Mariela Susana 2
  4. Fossati, María Pía 3
  5. Gurfinkel, Mirta 4
  6. Tellechea, Francisco 5
  7. Rodriguez Vazquez, María Luisa 6
  8. Dizeo, Claudio 7
  1. 1 Servicio de Cardiología de la Unidad Asistencial Por Más Salud Dr. César Milstein, Ciudad Autónoma de Buenos Aires (Argentina)
  2. 2 Coordinadora Unidad Coronaria, Hospital César Milstein
  3. 3 Laboratorio Central, Hospital César Milstein
  4. 4 Jefa Laboratorio Central, Hospital César Milstein
  5. 5 Medico de planta, Servicio Cardiología, Hospital César Milstein
  6. 6 Medica de planta Servicio Cardiología, Hospital César Milstein
  7. 7 Jefe del Servicio de Cardiología, Hospital César Milstein
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Journal:
Revista Argentina de Cardiología (RAC)

Year of publication: 2020

Volume: 88

Issue: 3

Pages: 194-200

Type: Article

DOI: 10.7775/AJC.88.3.17251 DIALNET GOOGLE SCHOLAR lock_openDialnet editor

Abstract

Purpose: The aim of this study was to assess whether interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP)associated with B-type natriuretic peptide (BNP) are independent markers of adverse events in outpatients with heart failureand reduced ejection fraction (HFrEF).Methods: Patients older than 65 years of age with HFrEF who were followed-up on an outpatient basis were prospectivelyincluded. Baseline BNP, IL-6 and hsCRP levels were assessed. Patients with HF after recent myocardial infarction (<6 months),and recent hospitalization (<3 months) due to a condition that could increase inflammatory markers were excluded fromthe analysis. The composite endpoint was all-cause mortality and hospitalization for decompensated heart failure (DHF).Results: A total of 130 patients aged 75 ± 5 years and with EF of 33 ± 11% were included in the study. The composite endpointwas observed in 31.5% (n=41) of patients during a follow-up period of 450 ± 210 days. In the multivariate analysis, elevatedBNP (>442 pg/ml) and elevated IL-6 (>7.2 pg/ml) were independent predictors of the primary endpoint [HR 2.60 (95% CI1.14-5.9), p=0.02 and HR 2.49 (95% CI 1.08-5.7), p=0.03, respectively], but not hsCRP >6.9 mg/l, p=0.2. IL-6 presented anarea under the ROC curve (AUC) of 0.70, BNP 0.73 and hsPCR 0.63, without significant differences between them.Conclusions: BNP and IL-6 were independent markers of the composite endpoint, but not CRP. The discrimination ability ofIL-6 and BNP was moderate.

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