Generalized implementation of reflex testing of hepatitis C in Galicia: Results for reflection

  1. Vallejo, Aldara 25
  2. Moldes, Luz María 28
  3. Trigo, Matilde 27
  4. Ordoñez, Patricia 23
  5. Rodriguez-Otero, Luis 12
  6. Cabrera, Jorge Julio
  7. Gude, María José 24
  8. Navarro, Daniel 25
  9. Cañizares, Angelina
  10. García-Campello, Marta
  11. Agulla, Andrés
  12. Aguilera, Antonio 256
  1. 1 Servicio de Microbiología, Complexo Hospitalario Universitario de Ourense, Ourense, Spain
  2. 2 Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela (La Coruña), Spain
  3. 3 Servicio de Microbiología, Complexo Hospitalario Arquitecto Marcide-Profesor Novoa Santos, Ferrol (La Coruña), Spain
  4. 4 Servicio de Microbiología, Hospital Universitario Lucus Augusti, Lugo, Spain
  5. 5 Servicio de Microbiología, Complexo Hospitalario Universitario de Santiago, Santiago de Compostela (La Coruña), Spain
  6. 6 Departamento de Microbioloxia e Parasitoloxía, Universidade de Santiago de Compostela, Santiago de Compostela (La Coruña), Spain
  7. 7 Servicio de Microbiología, Complexo Hospitalario de Pontevedra, Pontevedra, Spain
  8. 8 Servicio de Microbiología, Complexo Hospitalario Universitario de A Coruña, La Coruña, Spain
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Revista:
Enfermedades infecciosas y microbiologia clinica (English ed.)

ISSN: 2529-993X

Ano de publicación: 2022

Volume: 40

Número: 9

Páxinas: 483-488

Tipo: Artigo

DOI: 10.1016/J.EIMCE.2022.05.010 PMID: 35729051 SCOPUS: 2-s2.0-85101419997 GOOGLE SCHOLAR lock_openAcceso aberto editor

Outras publicacións en: Enfermedades infecciosas y microbiologia clinica (English ed.)

Resumo

IntroductionThe implementation of reflex testing of active hepatitis C virus (HCV) infection, together with the incorporation of informative alerts in the reports, has shown that it significantly reduces the number of patients who were not referred for therapeutic evaluation.MethodsSince the implementation in 2018 of the DUSP in the Microbiology Services of the Galician Health Service hospitals (SERGAS), new diagnoses of active HCV infection have been retrospectively identified and characterized.ResultsIn 2018, a total of 258 patients with unknown active HCV infection (70,2% men, middle age 52 years) were identified through by reflex testing from consultations of primary and specialized care units in 54.8% and 39.8% respectively, as well as from other locations by 5.4%. Of the 258 patients, 81.0% were referred for therapeutic evaluation, with a median of 54 days from their diagnosis. In 58.3% of the cases the reflex testing was determined by viral load, the predominant genotype was 1a (30,7%) and 52,1% were treated, observing sustained viral response (SVR) in 93.7 % of these.ConclusionThe generalized implementation of the HCV reflex testing together with informative alerts in Galicia has allowed us to obtain referral rates for treatment similar to those obtained in other studies. However, there is a wide variability between the different centers that require the incorporation of improvements, such as training or the use of rescue measures for optimization.

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