Publications by the researcher in collaboration with Jorge Christian Fernandez Masaguer (26)

2021

  1. 3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

    Journal of medicinal chemistry, Vol. 64, Núm. 1, pp. 458-480

2017

  1. Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

    Journal of Medicinal Chemistry, Vol. 60, Núm. 8, pp. 3372-3382

2014

  1. Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands

    European Journal of Medicinal Chemistry, Vol. 71, pp. 237-249

2013

  1. Synthesis and binding affinity of new 1,4-disubstituted triazoles as potential dopamine D3 receptor ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 23, Núm. 20, pp. 5586-5591

2011

  1. Potential atypical antipsychotics: Synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

    MedChemComm, Vol. 2, Núm. 12, pp. 1194-1200

2010

  1. Synthesis, 3D-QSAR, and structural modeling of benzolactam derivatives with binding affinity for the D2and D3 receptors

    ChemMedChem, Vol. 5, Núm. 8, pp. 1300-1317

2009

  1. Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 21, pp. 6059-6062

  2. Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands

    Bioorganic and Medicinal Chemistry Letters, Vol. 19, Núm. 6, pp. 1773-1778

2008

  1. Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics

    Journal of Medicinal Chemistry, Vol. 51, Núm. 19, pp. 6085-6094

2007

  1. Multistructure 3D-QSAR studies on a series of conformationally constrained butyrophenones docked into a new homology model of the 5-HT2A receptor

    Journal of Medicinal Chemistry, Vol. 50, Núm. 14, pp. 3242-3255

  2. Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 17, Núm. 17, pp. 4873-4877

2006

  1. QF2004B, a potential antipsychotic butyrophenone derivative with similar pharmacological properties to clozapine

    Neuropharmacology, Vol. 51, Núm. 2, pp. 251-262

2005

  1. Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 15, Núm. 12, pp. 3063-3066

2004

  1. Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics

    Bioorganic and Medicinal Chemistry Letters, Vol. 14, Núm. 3, pp. 585-589

2003

  1. Conformationally constrained butyrophenones as new pharmacological tools to study 5-HT2A and 5-HT2C receptor behaviours

    European Journal of Medicinal Chemistry

  2. In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: Comparison with prazosin, a known α1- adrenoceptor antagonist

    Vascular Pharmacology, Vol. 40, Núm. 2, pp. 97-108

2002

  1. New serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptor antagonists: Synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones

    Journal of Medicinal Chemistry, Vol. 45, Núm. 1, pp. 54-71

2000

  1. Butyrophenone analogues in the carbazole series as potential atypical antipsychotics: Synthesis and determination of affinities at D2, 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors

    European Journal of Medicinal Chemistry, Vol. 35, Núm. 1, pp. 83-95

  2. Conformationally constrained butyrophenones with affinity for dopamine (D1, D2, D4) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: Synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics

    Journal of Medicinal Chemistry, Vol. 43, Núm. 24, pp. 4678-4693

  3. Study of the in vivo and in vitro cardiovascular effects of four new analogues of ketanserin: Implication of 5-HT(2A) and α1 adrenergic antagonism in their hypotensive effect

    Biological and Pharmaceutical Bulletin, Vol. 23, Núm. 5, pp. 558-565