Publicaciones en colaboración con investigadores/as de Instituto de Química Médica (10)

2023

  1. 8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies

    European Journal of Medicinal Chemistry, Vol. 248

2022

  1. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

    Journal of medicinal chemistry, Vol. 65, Núm. 20, pp. 13660-13680

2021

  1. From the Design to the in Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

    Journal of Medicinal Chemistry, Vol. 64, Núm. 9, pp. 5429-5446

2020

  1. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis

    Journal of medicinal chemistry, Vol. 63, Núm. 17, pp. 9237-9257

2017

  1. Targeting PDE10A GAF domain with small molecules: A way for allosteric modulation with anti-inflammatory effects

    Molecules, Vol. 22, Núm. 9

2014

  1. Modulation of cAMP-specific PDE without emetogenic activity: New sulfide-like PDE7 inhibitors

    Journal of Medicinal Chemistry, Vol. 57, Núm. 20, pp. 8590-8607

2013

  1. Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

    European Journal of Medicinal Chemistry, Vol. 70, pp. 781-788

2012

  1. Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

    Journal of Medicinal Chemistry, Vol. 55, Núm. 7, pp. 3274-3284

  2. Identification in Silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

    ACS Chemical Neuroscience, Vol. 3, Núm. 10, pp. 793-803

  3. Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

    European Journal of Medicinal Chemistry, Vol. 47, Núm. 1, pp. 175-185