Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS)
Centro de investigación
Manuel José
Tena Sempere
Publicacións nas que colabora con Manuel José Tena Sempere (88)
2024
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Ceramides in the central control of metabolism
Trends in Endocrinology and Metabolism
2023
2022
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Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway
International Journal of Molecular Sciences, Vol. 23, Núm. 6
2021
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AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction
Metabolism: Clinical and Experimental, Vol. 115
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Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation
Nature Metabolism, Vol. 3, Núm. 10, pp. 1415-1431
2020
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AMPK-Dependent Mechanisms but Not Hypothalamic Lipid Signaling Mediates GH-Secretory Responses to GHRH and Ghrelin
Cells, Vol. 9, Núm. 9
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Central Ceramide Signaling Mediates Obesity-Induced Precocious Puberty
Cell Metabolism, Vol. 32, Núm. 6, pp. 951-966.e8
2018
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Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress
Cell Reports, Vol. 25, Núm. 2, pp. 413-423.e5
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Metabolic regulation of female puberty via hypothalamic AMPK-kisspeptin signaling
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, Núm. 45, pp. E10758-E10767
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SF1-specific AMPKa1 deletion protects against diet-induced obesity
Diabetes, Vol. 67, Núm. 11, pp. 2213-2226
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SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression
Nature Communications, Vol. 9, Núm. 1
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Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice
Metabolism: Clinical and Experimental, Vol. 87, pp. 87-97
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mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol
Journal of Endocrinology, Vol. 238, Núm. 3, pp. 177-186
2017
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Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?
Pharmacology and Therapeutics, Vol. 178, pp. 109-122
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Estradiol regulation of brown adipose tissue thermogenesis
Advances in Experimental Medicine and Biology (Springer New York LLC), pp. 315-335
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Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Cell Metabolism, Vol. 26, Núm. 1, pp. 212-229.e12
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Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats
International Journal of Neuropsychopharmacology, Vol. 20, Núm. 12, pp. 1005-1012
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Reduction of hypothalamic endoplasmic reticulum stress activates browning of white fat and ameliorates obesity
Diabetes, Vol. 66, Núm. 1, pp. 87-99
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Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue
Scientific Reports, Vol. 7
2016
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A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance
Cell Reports, Vol. 16, Núm. 8, pp. 2231-2242