Tratamiento del paciente alcohólico y del síndrome de abstinencia alcohólica

  1. M. Bermúdez Ramos 1
  2. E. Otero Antón 1
  3. S. Tomé 1
  1. 1 Complexo Hospitalario Universitario de Santiago
    info

    Complexo Hospitalario Universitario de Santiago

    Santiago de Compostela, España

    ROR https://ror.org/00mpdg388

Revista:
Medicine: Programa de Formación Médica Continuada Acreditado

ISSN: 0304-5412

Ano de publicación: 2016

Título do exemplar: Enfermedades del aparato digestivo (X) Enfermedades hepáticas

Serie: 12

Número: 10

Páxinas: 583-590

Tipo: Artigo

DOI: 10.1016/J.MED.2016.05.007 DIALNET GOOGLE SCHOLAR

Outras publicacións en: Medicine: Programa de Formación Médica Continuada Acreditado

Obxectivos de Desenvolvemento Sustentable

Resumo

Introduction Alcohol consumption is responsible for an overall mortality rate of 6%. Alcohol use disorders The alcohol abuse as well as alcohol dependence is now involved in a broader concept known of AUD (Alcohol Use Disorders). While acute alcohol produces a depressant effect of the central nervous system, chronic use produces an inhibition of the excitatory GABA system and superregulacion of glutamate, dopamine as well as an increased activation of the opioid system. Alcohol withdrawal syndrome Alcohol withdrawal syndrome occurs after cessation of chronic alcohol use and is the main complication of alcohol dependence. Treatment The most used drugs are benzodiazepines (GABA stimulators) for the wide therapeutic window, having no cross-tolerance with alcohol and antidote available in case of overdose. In chronic treatment should evaluate all modulating drugs of neurotransmitters involved.

Referencias bibliográficas

  • Longo DL, Schuckit MA. Recognition and management of withdrawal delirium (delirium tremens). N Engl J Med. 2014;371(22): 2109-13.
  • Mirijello A, D’Angelo C, Ferrulli A, Vassallo G, Antonelli M, Ca-puto F, et al. Identification and management of alcohol withdrawal syndrome. Drugs. 2015;75(4):353-65.
  • Carlson RW, Kumar NN, Wong-Mckinstry E, Ayyagari S, Puri N, Jackson FK, et al. Alcohol withdrawal syndrome. Critical Care Clin. 2012;28(4):549-85.
  • Sachdeva A, Choudhary M, Chandra M. Alcohol withdrawal syndrome: benzodiazepines and beyond. J Clin Diagn Res. 2015;9(9):VE01-VE07.
  • Steinberg MB, Chang PH. Alcohol withdrawal. Med Clin North Am. 2001;85(5):1191-212.
  • García ML. Alcohol liver disease: a review of current therapeutic approaches to achieve long-term abstinence. World J Gastroenterol. 2015; 21(28):8516.
  • Vonghia L, Leggio L, Ferrulli A, Bertini M, Gasbarrini G, Addolorato G. Acute alcohol intoxication. Eur J Inter Med. 2008; 19(8):561-67.
  • Behnke RH. Recognition and management of alcohol withdrawal syndrome. Hosp Pract. 1976;11(11):79-84.
  • Maldonado JR, Sher Y, Das S, Hills-Evans K, Frenklach A, Lolak S, et al. Prospective validation study of the prediction of alcohol withdrawal severity scale (pawss) in medically ill inpatients: a new scale for the prediction of complicated alcohol withdrawal syndrome. Alcohol Alcohol. 2015; 50(5):509-18.
  • Mayo-Smith MF, Beecher LH, Fischer TL, Gorelick DA, Guillaume JL, Hill A, et al. Management of alcohol withdrawal delirium: an evidence-based practice guideline. Arch Inter Med. 2004;164(13): 1405-12.
Fonte de datos: Dialnet