Hepatitis aguda virus E autóctonaUn diagnóstico en aumento. Análisis clínico-epidemiológico de nuestra experiencia

  1. Luzdivina Monteserín Ron 1
  2. Marcos Jiménez Palacios 1
  3. Pedro Linares Torres 1
  4. Aleida de Miguel Peña 1
  5. Begoña Álvarez Cuenllas 1
  6. Emilio D. Valverde Romero 1
  7. María Isabel Fernández Natal 1
  8. Francisco Jorquera Plaza 1
  1. 1 Complejo Asistencial Universitario de León
    info

    Complejo Asistencial Universitario de León

    León, España

    ROR https://ror.org/05gn84d31

Journal:
Revista Española de Enfermedades Digestivas

ISSN: 2340-416,  1130-0108

Year of publication: 2017

Volume: 109

Issue: 5

Pages: 344-349

Type: Article

DOI: 10.17235/REED.2017.4258/2016 DIALNET GOOGLE SCHOLAR

More publications in: Revista Española de Enfermedades Digestivas

Sustainable development goals

Abstract

Background: In Europe, acute hepatitis caused by the hepatitis E virus (HEV) traditionally was an infection found in people who had travelled to endemic zones, mainly Asia and Africa. However, a growing number of sporadic autochthonous cases are now being diagnosed in the Western world. Objective: To analyze the cases of acute HEV hepatitis diagnosed in our setting, with the identification of the clinicalepidemiological characteristics. Material and methods: We included the cases of acute HEV hepatitis diagnosed (positive anti-HEV IgM and/or HEV RNA present in serum) between January 2008 and December 2014. Different clinical, epidemiological and evolutive parameters were analyzed. Results: A total of 23 patients were identified, all originating from Spain. Fourteen cases (60.87%) presented jaundice and marked cytolysis at the time of diagnosis (aspartate aminotransferase [AST] 1,106.91 U/l and alanine aminotransferase [ALT] 1,407.04 U/l). Twenty-two cases were regarded as autochthonous, and one patient had travelled to China three months before. The mean time to resolution was 11.2 weeks. Some autoimmune markers were positive in 43.5% of the patients. Two subjects were diagnosed with previous chronic liver disease and were classified as “acuteon-chronic liver failure” (ACLF), one died and the other underwent liver transplantation. Conclusion: Acute HEV hepatitis in our setting is an autochthonous condition that is probably underdiagnosed, manifesting with jaundice and cytolysis. Autoimmune marker positivity is an epiphenomenon, which in some cases complicates the diagnosis

Data source: Dialnet