Demencia rápidamente progresiva por encefalitis límbica por anticuerpos LGI-1 y encefalopatía de Hashimoto. Presentación de dos casos y revisión de la literatura
- 1 Servicio de Medicina Interna. Complejo Hospitalario Universitario de Ourense
- Viñas Salas, Joan
ISSN: 0304-4866, 1989-3922
Ano de publicación: 2020
Volume: 81
Número: 2
Páxinas: 39-45
Tipo: Artigo
Outras publicacións en: Galicia Clínica
Resumo
Rapidly progressive dementias (RPD) are a very heterogeneous group of diseases characterized by acute cognitive impairment and behavioral disorders in a few weeks or months. Clinically most of times consists of memory loss, psychiatric disorders and epilepsy. Although RPD can be part of multiple clinical conditions, most common causes include autoimmune diseases, infectious or prion diseases and rarely, as a manifestation of a paraneoplastic syndrome. Image studies, cerebral spinal fluid evaluation, and serologic tests such as antigen determination are the most useful in diagnosing a neurological paraneoplastic syndrome. It’s very interesting an early diagnosis because the treatment is more effective in the early stages of illnes and can prevent irreversible neuronal damage. We present two cases of patients with rapidly cognitive impairmen due to limbic encephalitis and Hashimoto encephalopathy, rare but reversible causes of dementia.