Antiagregación plaquetaria dual y nivel de hemoglobina: un estudio observacional

  1. M.P. Quinteiro-Alonso 1
  2. M. González-Cao 2
  3. C. Barreales-Cardín 3
  4. G.J. Díaz-Grávalos 4
  1. 1 Centro de Salud Ribadavia, Ourense, España
  2. 2 Centro de Salud San Amaro, Ourense, España
  3. 3 Centro de Salud O Carballiño, Ourense, España
  4. 4 Centro de Salud Cea, Ourense, España
Semergen: revista española de medicina de familia

ISSN: 1138-3593

Ano de publicación: 2016

Número: 5

Páxinas: 293-297

Tipo: Artigo


Outras publicacións en: Semergen: revista española de medicina de familia

Objetivos de desarrollo sostenible


Introduction To determine the degree of association between dual antiplatelet therapy (DAPT) (clopidogrel plus acetylsalicylic acid) and haemoglobin (Hb) in clinical practice. Material and methods A retrospective longitudinal analysis was conducted on all patients on DAPT for at least 6 months. The required sample size was 63 patients. Hb value was determined before DAPT and at least 6 months after, as well as length of treatment, drugs, and diseases that might reduce the Hb. Changes in Hb after DAPT and the emergence or worsening of pre-existing anaemia was determined. Before and after Hb was compared using the t-test for paired samples. The occurrence of anaemia was considered dependent variable in a logistic regression analysis. Results A total of 122 cases were included. There were 92 (75.4%) males, and the mean age was 74.5 (SD 9.9) years. DAPT duration was 19.3 (11.8) months. The pre-treatment Hb was 14.3 (1.4) g/dl and 12.8 (1.9) g/dl post-treatment. The prevalence of pre-DAPT anaemia was 9.1% (11 cases), and 45.9% post-treatment (56 cases). Comparison of means showed a decrease of 1.5 g/dl (1.6) (95% CI; 1.2-1.8, P < .001). Anaemia post-treatment was associated with concomitant causes of anaemia, bleeding in the follow-up, and inversely with pre-treatment Hb level. Conclusions DAPT is associated with a decrease in Hb. Anaemia or worsening of previous anaemia appeared in about half of the subjects, and this effect was most likely in patients with bleeding in the follow-up and if other causes of anaemia were present.